Postagens
2013
Effect of glutamine supplementation on neutrophil function in male judoists ( 
Article in press 
)
Sasaki, E.a
, Umeda, T.a, Takahashi, I.a, Arata, K.b, Yamamoto, Y.b, Tanabe, M.ab, Oyamada, K.a, Hashizume, E.c, Nakaji, S.a
, Umeda, T.a, Takahashi, I.a, Arata, K.b, Yamamoto, Y.b, Tanabe, M.ab, Oyamada, K.a, Hashizume, E.c, Nakaji, S.a
a Department of Social Medicine Hirosaki University Graduate School of Medicine Hirosaki, Aomori Japan
b Department of Physical Education Nippon Sport Science University Setagaya Tokyo Japan
c Healthcare Products Development Center Kyowa Hakko Bio Co., Ltd. Tsukuba Japan
b Department of Physical Education Nippon Sport Science University Setagaya Tokyo Japan
c Healthcare Products Development Center Kyowa Hakko Bio Co., Ltd. Tsukuba Japan
Abstract
Glutamine is an important amino acid for immune function. Though high intensity and prolonged exercise decreases plasma glutamine concentration and causes immune suppression, the relationship between neutrophil functions and glutamine has not yet been found. The purpose of this study was to investigate the impacts of glutamine supplementation on neutrophil function. Twenty-six male university judoists were recruited. Subjects were classified into glutamine and control groups. The glutamine group ingested 3000 mg of glutamine per day and the control group ingested placebo for 2 weeks. Examinations were performed at the start of preunified loading exercise (pre-ULE), then 1 and 2 weeks after ULE (post-ULE). Reactive oxygen species (ROS) production, phagocytic activity, serum opsonic activity and serum myogenic enzymes were measured. Differences between the levels obtained in pre-ULE and post-ULE for the two groups were compared. In the glutamine group, ROS production activity increased 1 week after ULE, whereas it was not observed in the control group (P<0 .001="" activity="" after="" an="" and="" by="" damage="" during="" enzymes="" especially="" even="" excessive="" function="" glutamine="" group="" has="" in="" increased="" intensive="" muscle="" myogenic="" nbsp="" neutrophil="" of="" p="" period.="" prevented="" production="" remained="" ros="" significantly="" supplementation="" suppression="" the="" though="" training="" ule.="" ule="" unchanged="">
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